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Berberine diabetes infographic12/10/2023 For example, metformin can have gastrointestinal effects, sulfonylureas can cause hypoglycemia, and glucagon-like peptide-1 analogs can induce gastrointestinal reactions and antibody formation. However, adverse reactions or side effects can be associated with their use, albeit benefits that outweigh the risks. Oral hypoglycemic drugs have been widely used in China as the recommended first-line treatment, and these can effectively reduce blood glucose. Retrospectively registered on 18 October 2017.Īccording to the latest national epidemiological survey of diabetes, China has prevalence rates of 9.7% and 15.5% for diabetes and pre-diabetes, respectively, among people of over 20 years of age, and it has become one of the countries with the largest number of diabetic patients. It may provide support for the use of berberine and bifidobacteria in the treatment of diabetes. This is the first randomized controlled trial to determine the hypoglycemic effect and safety of both bifidobacteria and berberine administration to newly diagnosed patients with pre-diabetes or diabetes mellitus. The primary outcome is the absolute value of fasting plasma glucose compared with baseline after 16 weeks of treatment. The 300 randomized patients will be assigned to the following four groups for 16 weeks’ treatment: Bifidobacterium, berberine, Bifidobacterium combined berberine, and placebo control groups. This is a multicenter, double-blind, randomized, and parallel-controlled study that includes a run-in period of 2 weeks and a treatment period of 16 weeks, which will be conducted between June 2015 and October 2018. This study was designed to determine the hypoglycemic effect and safety of both bifidobacteria and berberine administration to newly diagnosed patients with pre-diabetes or diabetes mellitus. Unfortunately, there has been a shortage of relevant research on this possibility at the population level. In addition, the use of probiotic biotherapy to maintain an appropriate intestinal flora may represent an effective early intervention for hyperglycemia. Berberine is one of the most important examples of a Chinese traditional medicine that has hypoglycemic effects but there have been no randomized controlled trials of the drug in a larger sample.
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